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Bronchiectasis Interventional Study (BIS): the Torres Strait experience

2010 PHC Research Conference: Poster abstract


Organisation
Aims & rationale/Objectives
Rationale:
Bronchiectasis is a chronic suppurative lung condition which has a much higher rate in Indigenous people than non-Indigenous people. It often establishes in childhood, with the cause most often being pneumonia, and affects individuals throughout their life. Studies have shown that azithromycin is effective in those with cystic fibrosis. The optimal treatment of bronchiectasis in Indigenous populations is not known, due to a lack of studies. The Torres Strait cohort is part of a multicentre international study.

Objectives:
To contribute data from the Torres Strait, as part of a multicentre study, to:
1. Evaluate long-term treatment with azithromycin compared to placebo in the prevention of pulmonary exacerbations of bronchiectasis
2. Assess the impact of azithromycin treatment on antibiotic resistance.
Methods
- Recruitment commenced in the Torres Strait in October 2009, through the visiting paediatrics respiratory clinic and referrals from local health care providers.
- Randomised double-blind placebo-controlled trial comparing once-weekly azithromycin with placebo.
- Clinical history and assessments at first visit and subsequent visits at months 3, 6 , 9 & 12.
Principal findings
- Five subjects enrolled: Median age 5.0 years; age range 3.3-6.9 years; male :female 3:2.
- Causes of Bronchiectasis: Post-pneumonia (4), prematurity (1)
- Withdrawals: 1 subject due to medication refusal by the subject
Implications
- Community and practitioner awareness of Bronchiectasis.
- Close follow-up of children with bronchiectasis in the Torres Strait.
Presentation type
Poster
Session theme
Response to local needs
Presentation
Open document.  PDF 676.2 Kb
Citation
Tjhung I, Chang A. (2010). Bronchiectasis Interventional Study (BIS): the Torres Strait experience. In: 2010 Primary Health Care Research Conference: Program & Abstracts. Primary Health Care Research and Information Service, Australia. phcris.org.au/conference/abstract/6867

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