Bronchiectasis Interventional Study (BIS): the Torres Strait experience
2010 PHC Research Conference: Poster abstract
Bronchiectasis is a chronic suppurative lung condition which has a much higher rate in Indigenous people than non-Indigenous people. It often establishes in childhood, with the cause most often being pneumonia, and affects individuals throughout their life. Studies have shown that azithromycin is effective in those with cystic fibrosis. The optimal treatment of bronchiectasis in Indigenous populations is not known, due to a lack of studies. The Torres Strait cohort is part of a multicentre international study.
To contribute data from the Torres Strait, as part of a multicentre study, to:
1. Evaluate long-term treatment with azithromycin compared to placebo in the prevention of pulmonary exacerbations of bronchiectasis
2. Assess the impact of azithromycin treatment on antibiotic resistance.
- Randomised double-blind placebo-controlled trial comparing once-weekly azithromycin with placebo.
- Clinical history and assessments at first visit and subsequent visits at months 3, 6 , 9 & 12.
- Causes of Bronchiectasis: Post-pneumonia (4), prematurity (1)
- Withdrawals: 1 subject due to medication refusal by the subject
- Close follow-up of children with bronchiectasis in the Torres Strait.
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